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Use Embase to find drug names, synonyms and CAS Registry Numbers
Scientific literature rarely discusses compounds by their brand names, making the knowledge of preferred terms, synonyms and CAS® Registry Number(s) important when attempting to cast a wide net for search results.
Start with Embase® (File 73). All you have to do is EXPAND on a drug name in parentheses to find the preferred term. Then EXPAND the preferred name. SELECT the preferred term, the synonyms and the CAS Registry Number(s) — and you’re good to go to the peer-reviewed literature with confidence.
Once you have SELECTED the appropriate terms, ADD MEDLINE® (File 155), BIOSIS Previews® (File 5) and SciSearch®: A Cited Reference Science Database (File 34). Want to make MEDLINE the default database in duplicate detection? No problem: simply SET FILES 155,73,5,34.
In this example we searched for peer-reviewed literature for EXELON, a drug used to treat moderate dementia caused by Alzheimer’s disease.
? b 73
File 73:EMBASE 1974-2012/Oct 10
(c) 2012 Elsevier B.V.
Set Items Description
--- ----- -----------
? e (exelon)EXPAND the drug name using parentheses
Ref Items Type RT Index-term
R1 943 1 *EXELON
R2 4675 U 22 RIVASTIGMINEThis is the preferred term
Enter P or PAGE for more
? e r2EXPAND the R Reference number for the preferred term
Ref Items Type RT Index-term
R1 4675 22 *RIVASTIGMINE
R2 14071 B 78 CHOLINESTERASE INHIBITOR
R3 3290 B 213 NOOTROPIC AGENT
R4 85 S 1 ENA 713
R5 6 S 1 ENA713
R6 943 S 1 EXELON
R7 5 S 1 EXELON PATCH
R8 0 S 1 N ETHYL N METHYLCARBAMIC ACID [3 (1 DIMETHYLAM
R9 0 S 1 N ETHYL 3 [1 (DIMETHYLAMINO)ETHYL] N METHYLPHE
R10 1 S 1 NIMVASTID
R11 25 S 1 PROMETAX
R12 55 S 1 RIVASTIGMIN
R13 0 S 1 RIVASTIGMINE HYDROGEN TARTRATE
R14 0 S 1 RIVASTIGMINE TARTRATE
R15 52 S 1 SDZ ENA 713
R16 0 S 1 SDZ ENA713
R17 4 S 1 SDZ 212 713
R18 0 S 1 SDZ 212-713
R19 1 S 1 SDZ 212713
R20 0 S 1 SDZ212 713
R21 0 S 1 SDZ212-713
R22 0 S 1 SDZ212713
R23 4340 S 1 RN=129101-54-8
Enter P or PAGE for more
? s r1 or r4:r23Select the R Reference Number of the Preferred term and those
labeled S in the Type column
4675 RIVASTIGMINE
4370 ENA 713:RN=129101-54-8
S1 4680 'RIVASTIGMINE' OR R4:R23
? add 155,5,34ADD Files 155, 5 and 34
SYSTEM:OS - DIALOG OneSearch
You have 4 files in your file list.
Set Items Description
--- ----- -----------
Added File(s): 155, 5, 34
Previous sets have been retained; enter DISPLAY SETS to view them.
? set files 155,73,5,34Change the database order
New file order: 155, 73, 5, 34
? repeatRerun the search with the added databases
8293 RIVASTIGMINE
4370 ENA 713:RN=129101-54-8
S1 8298 'RIVASTIGMINE' OR R4:R23
? s s1/2011:2012LIMIT to a publication year range
8298 S1
7173371 PY=2011 : PY=2012
S2 1179 S1/2011:2012
? rdREMOVE DUPLICATES
S3 786 RD (unique items)
? t s3/8/1 from eachTYPE the first record FROM EACH of the databases
Dialog eLink:
3/8/1 (Item 1 from file: 73)
DIALOG(R)File 73: EMBASE
(c) 2012 Elsevier B.V. All rights reserved.
0088235713 EMBASE/MEDLINE No: 70889720 Management of dementia, a nonmotor feature of Parkinson disease